Description
Product Characteristics:
Syntenin-2 is a 292 amino acid protein that contains two PDZ (DHR) domains and functions as either a monomer or a homodimer that interacts with syntenin-1. Multiple isoforms of syntenin-2 exist and are encoded by a gene which maps to human chromosome 20. Comprising approximately 2 % of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception.
Subcellular location: Cytoplasm, Nucleus, Cell membrane
Synonyms: Syntenin-2, MDA9, Melanoma dferentiation associated gene 9, Pro TGF alpha cytoplasmic domain interacting protein 18, SDCB2_HUMAN, SDCBP2, SITAC, SITAC18, ST 2, Syndecan binding protein syntenin 2, Syndecan binding protein 2, Syndecan-binding protein 2.
Target Information: The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]